6BR1

Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 4a

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Tubulin alpha-1B chain	polymer	450	50041.3	2	UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953)	Sus scrofa (Pig)	Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
2	B, D (B, D)	Tubulin beta-2B chain	polymer	445	49999.9	2	UniProt (A0A287AGU7) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (P02554)	Sus scrofa (Pig)
3	E (E)	Stathmin-4	polymer	143	16844.2	1	UniProt (Q9H169) Pfam (PF00836)	Homo sapiens (Human)	Stathmin-like protein B3,RB3
4	F (F)	Tubulin tyrosine ligase	polymer	384	44378.5	1	UniProt (E1BQ43)	Gallus gallus (Chicken)
5	G, O (A, C)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP)
6	H, P (A, C)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
7	I, M, Q, T (A, B, C, F)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
8	J, R (B, D)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
9	K, L (B)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	2	Chemie (MES)
10	N, S (B, D)	2-chloro-4-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)pyrido[2,3-d]pyrimidine	non-polymer		326.8	2	Chemie (E3Y)
11	U (F)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	1	Chemie (ACP)
12	AA, V, W, X, Y... (F, A, B, C, D...)	water	water		18.0	697	Chemie (HOH)

Sequence modifications

E: 5 - 145 (UniProt: Q9H169)

PDB	External Database	Details
Met 3	-	expression tag
Ala 4	-	expression tag

F: 1 - 378 (UniProt: E1BQ43)

PDB	External Database	Details
His 379	-	expression tag
His 380	-	expression tag
His 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	261305.0
Non-Polymers*	Number of molecules	15
	Total formula weight	3659.4
All*	Total formula weight	264964.4

*Water molecules are not included.