6BQL
Crystal Structure of the Human CAMKK2B in complex with TAE-226
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Calcium/calmodulin-dependent protein kinase kinase 2 | polymer | 291 | 33127.3 | 1 | UniProt (Q96RR4) Pfam (PF00069) | Homo sapiens (Human) | CaMKK 2,Calcium/calmodulin-dependent protein kinase kinase beta,CaMKK beta |
| 2 | B (A) | 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE | non-polymer | 468.9 | 1 | Chemie (BI9) | |||
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | E, F (A) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 6 | G (A) | AMMONIUM ION | non-polymer | 18.0 | 1 | Chemie (NH4) | |||
| 7 | H (A) | water | water | 18.0 | 112 | Chemie (HOH) |
Sequence modifications
A: 161 - 449 (UniProt: Q96RR4)
| PDB | External Database | Details |
|---|---|---|
| Ser 159 | - | expression tag |
| Met 160 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33127.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 702.6 | |
| All* | Total formula weight | 33829.8 |
