6BQG
Crystal structure of 5-HT2C in complex with ergotamine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562 | polymer | 452 | 51310.1 | 1 | UniProt (P28335) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) | Homo sapiens (Human) | 5-HTR2C,5-hydroxytryptamine receptor 1C,5-HT1C,Serotonin receptor 2C,Cytochrome b-562 |
| 2 | B (A) | Ergotamine | non-polymer | 581.7 | 1 | Chemie (ERM) | |||
| 3 | C (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 1 | Chemie (OLC) |
Sequence modifications
A: 40 - 245 (UniProt: P28335)
A: 1001 - 1106 (UniProt: P0ABE7)
A: 301 - 393 (UniProt: P28335)
| PDB | External Database | Details |
|---|---|---|
| Met 14 | - | expression tag |
| Lys 15 | - | expression tag |
| Thr 16 | - | expression tag |
| Ile 17 | - | expression tag |
| Ile 18 | - | expression tag |
| Ala 19 | - | expression tag |
| Leu 20 | - | expression tag |
| Ser 21 | - | expression tag |
| Tyr 22 | - | expression tag |
| Ile 23 | - | expression tag |
| Phe 24 | - | expression tag |
| Cys 25 | - | expression tag |
| Leu 26 | - | expression tag |
| Val 27 | - | expression tag |
| Phe 28 | - | expression tag |
| Ala 29 | - | expression tag |
| Asp 30 | - | expression tag |
| Tyr 31 | - | expression tag |
| Lys 32 | - | expression tag |
| Asp 33 | - | expression tag |
| Asp 34 | - | expression tag |
| Asp 35 | - | expression tag |
| Asp 36 | - | expression tag |
| Gly 37 | - | expression tag |
| Ala 38 | - | expression tag |
| Pro 39 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp 1007 | Met 29 | engineered mutation |
| Ile 1102 | His 124 | engineered mutation |
| Leu 1106 | Arg 128 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 360 | Cys 360 | engineered mutation |
| Gly 394 | - | expression tag |
| Arg 395 | - | expression tag |
| Pro 396 | - | expression tag |
| Leu 397 | - | expression tag |
| Glu 398 | - | expression tag |
| Val 399 | - | expression tag |
| Leu 400 | - | expression tag |
| Phe 401 | - | expression tag |
| Gln 402 | - | expression tag |
| Gly 403 | - | expression tag |
| Pro 404 | - | expression tag |
| His 405 | - | expression tag |
| His 406 | - | expression tag |
| His 407 | - | expression tag |
| His 408 | - | expression tag |
| His 409 | - | expression tag |
| His 410 | - | expression tag |
| His 411 | - | expression tag |
| His 412 | - | expression tag |
| His 413 | - | expression tag |
| His 414 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 51310.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 938.2 | |
| All* | Total formula weight | 52248.3 |
