6BLN
BTK complex with compound 13
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase BTK | polymer | 287 | 33878.7 | 1 | UniProt (Q06187) Pfam (PF07714) In PDB | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
2 | A | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
3 | A | N-(3-{5-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}-2,6-difluorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | non-polymer | 496.5 | 1 | Chemie (DY4) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | water | water | 18.0 | 234 | Chemie (HOH) |
Sequence modifications
A: 393 - 657 (UniProt: Q06187)
PDB | External Database | Details |
---|---|---|
Met 392 | - | initiating methionine |
Asn 658 | - | expression tag |
Leu 659 | - | expression tag |
Tyr 660 | - | expression tag |
Phe 661 | - | expression tag |
Gln 662 | - | expression tag |
Gly 663 | - | expression tag |
Glu 664 | - | expression tag |
Glu 665 | - | expression tag |
Tyr 666 | - | expression tag |
Met 667 | - | expression tag |
Pro 668 | - | expression tag |
Thr 669 | - | expression tag |
Glu 670 | - | expression tag |
His 671 | - | expression tag |
His 672 | - | expression tag |
His 673 | - | expression tag |
His 674 | - | expression tag |
His 675 | - | expression tag |
His 676 | - | expression tag |
His 677 | - | expression tag |
His 678 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 33878.7 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 876.8 | |
All* | Total formula weight | 34755.5 |