6BKQ
Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin E190D mutant in complex with 6'-SLN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, C, E) | Hemagglutinin | polymer | 323 | 35492.9 | 3 | UniProt (Q91MA7) Pfam (PF00509) | Influenza A virus (strain A/Hong Kong/1/1968 H3N2) | |
| 2 | B, D, F (B, D, F) | Hemagglutinin | polymer | 174 | 20041.1 | 3 | UniProt (Q91MA7) Pfam (PF00509) | Influenza A virus (strain A/Hong Kong/1/1968 H3N2) | |
| 3 | G, H (G, H) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 4 | I, L, O (I, L, O) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 5 | J, M (J, M) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 674.6 | 2 | In PDB BIRD (PRD_900046) GlyTouCan (G73578JC) | 6'-sialyl-N-acetyllactosamine | ||
| 6 | K, N (K, N) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 7 | P (P) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose | branched | 471.4 | 1 | In PDB GlyTouCan (G63069TR) | |||
| 8 | Q, R, S, U (A, C, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 9 | T, V (C, E) | TRIS(HYDROXYETHYL)AMINOMETHANE | non-polymer | 163.2 | 2 | Chemie (TAM) | |||
| 10 | AA, BA, W, X, Y... (E, F, A, B, C...) | water | water | 18.0 | 805 | Chemie (HOH) |
Sequence modifications
A, C, E: 11 - 329 (UniProt: Q91MA7)
B, D, F: 1 - 174 (UniProt: Q91MA7)
| PDB | External Database | Details |
|---|---|---|
| Ala 7 | - | expression tag |
| Asp 8 | - | expression tag |
| Pro 9 | - | expression tag |
| Gly 10 | - | expression tag |
| Asp 190 | Glu 206 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 123 | Arg 468 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 166602.2 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 6088.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1211.3 | |
| All* | Total formula weight | 173902.0 |
