6BIK
BTK complex with compound 7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase BTK | polymer | 287 | 33878.7 | 1 | UniProt (Q06187) Pfam (PF07714) | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | B, C, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | D (A) | 4-tert-butyl-N-[2-(hydroxymethyl)-3-(1-methyl-5-{[5-(morpholine-4-carbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridazin-3-yl)phenyl]benzamide | non-polymer | 596.7 | 1 | Chemie (DTJ) | |||
| 4 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | G (A) | water | water | 18.0 | 171 | Chemie (HOH) |
Sequence modifications
A: 393 - 657 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Met 392 | - | initiating methionine |
| Asn 658 | - | expression tag |
| Leu 659 | - | expression tag |
| Tyr 660 | - | expression tag |
| Phe 661 | - | expression tag |
| Gln 662 | - | expression tag |
| Gly 663 | - | expression tag |
| Glu 664 | - | expression tag |
| Glu 665 | - | expression tag |
| Tyr 666 | - | expression tag |
| Met 667 | - | expression tag |
| Pro 668 | - | expression tag |
| Thr 669 | - | expression tag |
| Glu 670 | - | expression tag |
| His 671 | - | expression tag |
| His 672 | - | expression tag |
| His 673 | - | expression tag |
| His 674 | - | expression tag |
| His 675 | - | expression tag |
| His 676 | - | expression tag |
| His 677 | - | expression tag |
| His 678 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33878.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 977.0 | |
| All* | Total formula weight | 34855.7 |
