6BHH
Crystal structure of SETDB1 with a modified H3 peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Histone-lysine N-methyltransferase SETDB1 | polymer | 239 | 27555.6 | 1 | UniProt (Q15047) Pfam (PF18300) Pfam (PF18359) Pfam (PF18358) In PDB | Homo sapiens (Human) | ERG-associated protein with SET domain, ESET, Histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, Lysine N-methyltransferase 1E, SET domain bifurcated 1 |
2 | B | Histone H3.1 | polymer | 18 | 1840.2 | 1 | UniProt (P68431) In PDB | Homo sapiens | Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l |
3 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
4 | A, B | UNKNOWN ATOM OR ION | non-polymer | 26 | Chemie (UNX) | ||||
5 | water | water | 18.0 | 221 | Chemie (HOH) |
Sequence modifications
A: 190 - 410 (UniProt: Q15047)
B: 4 - 19 (UniProt: P68431)
PDB | External Database | Details |
---|---|---|
Met 172 | - | expression tag |
His 173 | - | expression tag |
His 174 | - | expression tag |
His 175 | - | expression tag |
His 176 | - | expression tag |
His 177 | - | expression tag |
His 178 | - | expression tag |
Ser 179 | - | expression tag |
Ser 180 | - | expression tag |
Gly 181 | - | expression tag |
Arg 182 | - | expression tag |
Glu 183 | - | expression tag |
Asn 184 | - | expression tag |
Leu 185 | - | expression tag |
Tyr 186 | - | expression tag |
Phe 187 | - | expression tag |
Gln 188 | - | expression tag |
Gly 189 | - | expression tag |
Ala 358 | Trp 358 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ace 3 | - | acetylation |
Nh2 20 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 29395.8 | |
Non-Polymers* | Number of molecules | 28 |
Total formula weight | 192.1 | |
All* | Total formula weight | 29587.9 |