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6BHH

Crystal structure of SETDB1 with a modified H3 peptide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Histone-lysine N-methyltransferase SETDB1polymer23927555.61UniProt (Q15047)
Pfam (PF18300)
Pfam (PF18359)
Pfam (PF18358)
Homo sapiens (Human)ERG-associated protein with SET domain, ESET, Histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, Lysine N-methyltransferase 1E, SET domain bifurcated 1
2B
(B)
Histone H3.1polymer181840.21UniProt (P68431)Homo sapiensHistone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l
3C, D
(A)
SULFATE IONnon-polymer96.12Chemie (SO4)
4AA, BA, CA, DA, E...
(A, B)
UNKNOWN ATOM OR IONnon-polymer26Chemie (UNX)
5EA, FA
(A, B)
waterwater18.0221Chemie (HOH)
Sequence modifications
A: 190 - 410 (UniProt: Q15047)
PDBExternal DatabaseDetails
Met 172-expression tag
His 173-expression tag
His 174-expression tag
His 175-expression tag
His 176-expression tag
His 177-expression tag
His 178-expression tag
Ser 179-expression tag
Ser 180-expression tag
Gly 181-expression tag
Arg 182-expression tag
Glu 183-expression tag
Asn 184-expression tag
Leu 185-expression tag
Tyr 186-expression tag
Phe 187-expression tag
Gln 188-expression tag
Gly 189-expression tag
Ala 358Trp 358engineered mutation
B: 4 - 19 (UniProt: P68431)
PDBExternal DatabaseDetails
Ace 3-acetylation
Nh2 20-amidation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight29395.8
Non-Polymers*Number of molecules28
Total formula weight192.1
All*Total formula weight29587.9
*Water molecules are not included.

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PDB entries from 2025-07-02

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