6BGP
Crystal Structure of Human Calpain-3 Protease Core Mutant-C129A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Calpain-3 | polymer | 382 | 44424.1 | 4 | UniProt (P20807) Pfam (PF00648) | Homo sapiens (Human) | Calcium-activated neutral proteinase 3,CANP 3,Calpain L3,Calpain p94,Muscle-specific calcium-activated neutral protease 3,New calpain 1,nCL-1 |
| 2 | E, F, H, I, K... (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 3 | G, J, M, P (A, B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 4 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 46 - 419 (UniProt: P20807)
| PDB | External Database | Details |
|---|---|---|
| Ala 129 | Cys 129 | engineered mutation |
| Leu 420 | - | expression tag |
| Glu 421 | - | expression tag |
| His 422 | - | expression tag |
| His 423 | - | expression tag |
| His 424 | - | expression tag |
| His 425 | - | expression tag |
| His 426 | - | expression tag |
| His 427 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 177696.4 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 462.4 | |
| All* | Total formula weight | 178158.9 |
