6BFC
Cryo-EM structure of human insulin degrading enzyme in complex with insulin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Insulin-degrading enzyme | polymer | 966 | 111866.5 | 2 | UniProt (P14735) Pfam (PF00675) Pfam (PF05193) Pfam (PF16187) | Homo sapiens (Human) | Abeta-degrading protease,Insulin protease,Insulinase,Insulysin |
| 2 | C, D (a, b) | Insulin | polymer | 110 | 11989.9 | 2 | UniProt (P01308) Pfam (PF00049) | Homo sapiens (Human) |
Sequence modifications
A, B: 46 - 1011 (UniProt: P14735)
| PDB | External Database | Details |
|---|---|---|
| Leu 110 | Cys 110 | conflict |
| Ser 171 | Cys 171 | conflict |
| Ala 178 | Cys 178 | conflict |
| Val 257 | Cys 257 | conflict |
| Leu 414 | Cys 414 | conflict |
| Asn 573 | Cys 573 | conflict |
| Ser 590 | Cys 590 | conflict |
| Ser 789 | Cys 789 | conflict |
| Ala 812 | Cys 812 | conflict |
| Ala 819 | Cys 819 | conflict |
| Ser 904 | Cys 904 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 247712.7 | |
| All* | Total formula weight | 247712.7 |
