6BDT
Crystal Structure of Human Calpain-3 Protease Core Mutant-C129S
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Calpain-3 | polymer | 382 | 44440.1 | 4 | UniProt (P20807) Pfam (PF00648) In PDB | Homo sapiens (Human) | Calcium-activated neutral proteinase 3,CANP 3,Calpain L3,Calpain p94,Muscle-specific calcium-activated neutral protease 3,New calpain 1,nCL-1 |
2 | A, B, C, D | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
3 | A, B, C, D | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
4 | water | water | 18.0 | 113 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 46 - 419 (UniProt: P20807)
PDB | External Database | Details |
---|---|---|
Ser 129 | Cys 129 | engineered mutation |
Leu 420 | - | expression tag |
Glu 421 | - | expression tag |
His 422 | - | expression tag |
His 423 | - | expression tag |
His 424 | - | expression tag |
His 425 | - | expression tag |
His 426 | - | expression tag |
His 427 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 177760.4 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 462.4 | |
All* | Total formula weight | 178222.9 |