6BBV
Crystal Structure of JAK2 in complex with compound 25
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase JAK2 | polymer | 298 | 34873.7 | 1 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
| 2 | A | N-{cis-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | non-polymer | 323.4 | 1 | Chemie (D7D) | |||
| 3 | water | water | 18.0 | 172 | Chemie (HOH) |
Sequence modifications
A: 837 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Gly 835 | - | expression tag |
| Ser 836 | - | expression tag |
| Ser 1073 | Met 1073 | conflict |
| Thr 1076 | Phe 1076 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34873.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 323.4 | |
| All* | Total formula weight | 35197.1 |
