6BBU
Crystal Structure of JAK1 in complex with compound 25
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase JAK1 | polymer | 316 | 36417.5 | 1 | UniProt (P23458) Pfam (PF07714) | Homo sapiens (Human) | Janus kinase 1,JAK-1 |
| 2 | B (A) | N-{cis-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | non-polymer | 323.4 | 1 | Chemie (D7D) | |||
| 3 | C (A) | water | water | 18.0 | 127 | Chemie (HOH) |
Sequence modifications
A: 841 - 1154 (UniProt: P23458)
| PDB | External Database | Details |
|---|---|---|
| Gly 839 | - | expression tag |
| Ser 840 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36417.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 323.4 | |
| All* | Total formula weight | 36740.9 |
