6BAX

Lactate Dehydrogenase in complex with inhibitor 6-(3-aminophenyl)-3-((2-chlorophenyl)thio)-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	L-lactate dehydrogenase A chain	polymer	331	36603.5	4	UniProt (P00338) Pfam (PF00056) Pfam (PF02866)	Homo sapiens (Human)	LDH-A,Cell proliferation-inducing gene 19 protein,LDH muscle subunit,LDH-M,Renal carcinoma antigen NY-REN-59
2	E, I, L, O (A, B, C, D)	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	4	Chemie (NAD)
3	F, J, M (A, B, C)	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	3	Chemie (EPE)
4	G, P (A, D)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5	H, K, N, Q (A, B, C, D)	(6R)-6-(3-aminophenyl)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one	non-polymer		429.9	4	Chemie (D4S)
6	R, S, T, U (A, B, C, D)	water	water		18.0	649	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	146413.9
Non-Polymers*	Number of molecules	13
	Total formula weight	5280.5
All*	Total formula weight	151694.4

*Water molecules are not included.