6BAE

Trastuzumab Fab v3 in complex with CQFDLSTRRLKC

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Trastuzumab Fab light chain	polymer	214	23518.0	1	UniProt (P01834) Pfam (PF07654)	Mus musculus	Ig kappa chain C region,Ig kappa chain C region AG,Ig kappa chain C region CUM,Ig kappa chain C region EU,Ig kappa chain C region OU,Ig kappa chain C region ROY,Ig kappa chain C region TI
2	B (B)	Trastuzumab Fab heavy chain	polymer	223	23806.7	1	UniProt (S6B291) Pfam (PF07686) Pfam (PF07654)	Mus musculus
3	C (E)	Protein L	polymer	64	6907.7	1	UniProt (Q51918) Pfam (PF02246)	Finegoldia magna (Peptostreptococcus magnus)
4	D (C)	Immunoglobulin G binding protein A	polymer	54	6037.5	1	UniProt (Q2UW42) Pfam (PF02216) UniProt (by SIFTS) (P02976)	Staphylococcus aureus
5	E (D)	meditope	polymer	14	1496.8	1		synthetic construct
6	F, G, H, I, J (A, B, E, C, D)	water	water		18.0	535	Chemie (HOH)

Sequence modifications

A: 1 - 107 (PDB: 6BAE)
A: 108 - 214 (UniProt: P01834)
B: 1 - 108 (PDB: 6BAE)
B: 109 - 223 (UniProt: S6B291)

PDB	External Database	Details
Cys 175	Ala 191	engineered mutation
Lys 217	Arg 233	engineered mutation

E: 21 - 81 (UniProt: Q51918)

PDB	External Database	Details
Gly 18	-	expression tag
Ser 19	-	expression tag
Glu 20	-	expression tag
Ile 34	Thr 490	engineered mutation
Ala 55	Asp 511	engineered mutation
Asn 73	Tyr 529	engineered mutation
His 74	Thr 530	engineered mutation
Met 75	Ile 531	engineered mutation

C: 4 - 54 (UniProt: Q2UW42)

PDB	External Database	Details
Gly 1	-	expression tag
Ser 2	-	expression tag
Tyr 3	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	61766.7
All*	Total formula weight	61766.7

*Water molecules are not included.