6BAE
Trastuzumab Fab v3 in complex with CQFDLSTRRLKC
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Trastuzumab Fab light chain | polymer | 214 | 23518.0 | 1 | UniProt (P01834) Pfam (PF07654) In PDB | Mus musculus | Ig kappa chain C region,Ig kappa chain C region AG,Ig kappa chain C region CUM,Ig kappa chain C region EU,Ig kappa chain C region OU,Ig kappa chain C region ROY,Ig kappa chain C region TI |
2 | B | Trastuzumab Fab heavy chain | polymer | 223 | 23806.7 | 1 | UniProt (S6B291) Pfam (PF07686) Pfam (PF07654) In PDB | Mus musculus | |
3 | E | Protein L | polymer | 64 | 6907.7 | 1 | UniProt (Q51918) Pfam (PF02246) In PDB | Finegoldia magna (Peptostreptococcus magnus) | |
4 | C | Immunoglobulin G binding protein A | polymer | 54 | 6037.5 | 1 | UniProt (Q2UW42) Pfam (PF02216) UniProt (by SIFTS) (P02976) In PDB | Staphylococcus aureus | |
5 | D | meditope | polymer | 14 | 1496.8 | 1 | synthetic construct | ||
6 | water | water | 18.0 | 535 | Chemie (HOH) |
Sequence modifications
A: 1 - 107 (PDB: 6BAE)
A: 108 - 214 (UniProt: P01834)
B: 1 - 108 (PDB: 6BAE)
B: 109 - 223 (UniProt: S6B291)
E: 21 - 81 (UniProt: Q51918)
C: 4 - 54 (UniProt: Q2UW42)
A: 108 - 214 (UniProt: P01834)
B: 1 - 108 (PDB: 6BAE)
B: 109 - 223 (UniProt: S6B291)
PDB | External Database | Details |
---|---|---|
Cys 175 | Ala 191 | engineered mutation |
Lys 217 | Arg 233 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 18 | - | expression tag |
Ser 19 | - | expression tag |
Glu 20 | - | expression tag |
Ile 34 | Thr 490 | engineered mutation |
Ala 55 | Asp 511 | engineered mutation |
Asn 73 | Tyr 529 | engineered mutation |
His 74 | Thr 530 | engineered mutation |
Met 75 | Ile 531 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Ser 2 | - | expression tag |
Tyr 3 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 61766.7 | |
All* | Total formula weight | 61766.7 |