6B7Z
Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11 heavy chain and FAB H11 light chain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Insulin-degrading enzyme | polymer | 966 | 111866.5 | 2 | UniProt (P14735) Pfam (PF00675) Pfam (PF05193) Pfam (PF16187) | Homo sapiens (Human) | Abeta-degrading protease,Insulin protease,Insulinase,Insulysin |
| 2 | C, E (C, E) | FAB H11 heavy chain | polymer | 218 | 23057.7 | 2 | UniProt (P0DOX5) Pfam (PF07686) Pfam (PF07654) | Mus musculus (Mouse) | |
| 3 | D, F (D, F) | FAB H11 light chain | polymer | 211 | 23087.6 | 2 | UniProt (Q6GMX0) Pfam (PF07686) Pfam (PF07654) | Mus musculus (Mouse) |
Sequence modifications
A, B: 46 - 1011 (UniProt: P14735)
C, E: 4 - 126 (PDB: 6B7Z)
C, E: 127 - 221 (UniProt: P0DOX5)
D, F: 2 - 105 (PDB: 6B7Z)
D, F: 106 - 212 (UniProt: Q6GMX0)
| PDB | External Database | Details |
|---|---|---|
| Leu 110 | Cys 110 | conflict |
| Ser 171 | Cys 171 | conflict |
| Ala 178 | Cys 178 | conflict |
| Val 257 | Cys 257 | conflict |
| Leu 414 | Cys 414 | conflict |
| Asn 573 | Cys 573 | conflict |
| Ser 590 | Cys 590 | conflict |
| Ser 789 | Cys 789 | conflict |
| Ala 812 | Cys 812 | conflict |
| Ala 819 | Cys 819 | conflict |
| Ser 904 | Cys 904 | conflict |
C, E: 127 - 221 (UniProt: P0DOX5)
D, F: 2 - 105 (PDB: 6B7Z)
D, F: 106 - 212 (UniProt: Q6GMX0)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 316023.7 | |
| All* | Total formula weight | 316023.7 |
