6B77
Structures of the two-chain human plasma factor XIIa co-crystallized with potent inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Coagulation factor XII | polymer | 9 | 932.0 | 1 | UniProt (P00748) | Homo sapiens (Human) | Hageman factor,HAF |
| 2 | B (B) | Coagulation factor XII | polymer | 243 | 26127.4 | 1 | UniProt (P00748) Pfam (PF00089) | Homo sapiens (Human) | Hageman factor,HAF |
| 3 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D (B) | [3-(1-aminoisoquinolin-6-yl)phenyl]boronic acid | non-polymer | 264.1 | 1 | Chemie (CWV) | |||
| 5 | E, F (B) | IODIDE ION | non-polymer | 126.9 | 2 | Chemie (IOD) | |||
| 6 | G, H, I (B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 7 | J (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 8 | K, L (A, B) | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27059.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 898.2 | |
| All* | Total formula weight | 28382.0 |
