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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6B6H

The cryo-EM structure of a bacterial class I transcription activation complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)		DNA-directed RNA polymerase subunit alphapolymer32936558.72UniProt (P0A7Z6)
Pfam (PF01193)
Pfam (PF01000)
Pfam (PF03118)
UniProt (by SIFTS) (P0A7Z4)		Escherichia coli O157:H7RNAP subunit alpha,RNA polymerase subunit alpha,Transcriptase subunit alpha
2C
(C)		DNA-directed RNA polymerase subunit betapolymer1342150820.91UniProt (B7MIX3)
Pfam (PF04560)
Pfam (PF04563)
Pfam (PF04561)
Pfam (PF04565)
Pfam (PF10385)
Pfam (PF00562)
UniProt (by SIFTS) (P0A8V2)		Escherichia coli O45:K1 (strain S88 / ExPEC)RNAP subunit beta,RNA polymerase subunit beta,Transcriptase subunit beta
3D
(D)		DNA-directed RNA polymerase subunit beta'polymer1407155366.81UniProt (P0A8T8)
Pfam (PF04997)
Pfam (PF00623)
Pfam (PF04983)
Pfam (PF05000)
Pfam (PF04998)
UniProt (by SIFTS) (P0A8T7)		Escherichia coli O157:H7RNAP subunit beta',RNA polymerase subunit beta',Transcriptase subunit beta'
4E
(E)		DNA-directed RNA polymerase subunit omegapolymer9110249.51UniProt (B7MFL0)
Pfam (PF01192)
UniProt (by SIFTS) (P0A800)		Escherichia coli O45:K1RNAP omega subunit,RNA polymerase omega subunit,Transcriptase subunit omega
5F
(F)		RNA polymerase sigma factor RpoDpolymer62872206.31UniProt (P00579)
Pfam (PF03979)
Pfam (PF00140)
Pfam (PF04546)
Pfam (PF04542)
Pfam (PF04539)
Pfam (PF04545)		Escherichia coli (strain K12)Sigma-70
6G, H
(G, H)		cAMP-activated global transcriptional regulator CRPpolymer21023672.42UniProt (P0ACK0)
Pfam (PF00027)
Pfam (PF13545)
UniProt (by SIFTS) (P0ACJ8)		Escherichia coli O157:H7Catabolite activator protein,CAP,Catabolite gene activator,cAMP receptor protein,CRP,cAMP regulatory protein
7I
(I)		DNA-directed RNA polymerase subunit alphapolymer758346.71UniProt (P0A7Z6)
Pfam (PF03118)
UniProt (by SIFTS) (P0A7Z4)		Escherichia coli O157:H7RNAP subunit alpha,RNA polymerase subunit alpha,Transcriptase subunit alpha
8J
(1)		SYNTHETIC NONTEMPLATE STRAND DNA (88-MER)polymer8827133.41Escherichia coli
9K
(2)		SYNTHETIC TEMPLATE STRAND DNA (88-MER)polymer8827217.41Escherichia coli
10L
(3)		NASCENT RNA 3-MERpolymer31134.61Escherichia coliNASCENT RNA 3-MER
11M, N
(D)		ZINC IONnon-polymer65.42Chemie (ZN)
12O
(D)		MAGNESIUM IONnon-polymer24.31Chemie (MG)
PubChem (888)
13P, Q
(G, H)		ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATEnon-polymer329.22Chemie (CMP)
PubChem (23902375)
PubChem (25322948)
PubChem (176488666)
PubChem (25322946)
PubChem (40467852)
PubChem (59350541)
PubChem (44629928)
PubChem (274)
PubChem (6604194)
PubChem (56973690)
PubChem (163043517)
PubChem (59909322)
PubChem (59968988)
PubChem (70878457)
PubChem (6076)
PubChem (124132380)
PubChem (216878)
PubChem (3080770)
PubChem (3246347)
PubChem (6603718)
PubChem (6713792)
PubChem (6714006)
PubChem (129317551)
PubChem (12071879)
PubChem (12866365)
PubChem (131841987)
PubChem (134693155)
PubChem (138107790)
PubChem (163043518)
Sequence modifications
F: 1 - 613 (UniProt: P00579)
PDBExternal DatabaseDetails
Met -14-initiating methionine
Arg -13-expression tag
Gly -12-expression tag
Ser -11-expression tag
His -10-expression tag
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
Thr -4-expression tag
Asp -3-expression tag
Gln -2-expression tag
Phe -1-expression tag
Thr 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains12
Total formula weight572937.8
Non-Polymers*Number of molecules5
Total formula weight813.5
All*Total formula weight573751.4
*Water molecules are not included.

253795

PDB entries from 2026-05-20

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