6B4L
Crystal structure of MCL-1 in complex with a BIM competitive inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 157 | 17882.4 | 2 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | C, D (A, B) | 3-{3-[(naphthalen-1-yl)oxy]propyl}-1H-indole-2-carboxylic acid | non-polymer | 345.4 | 2 | Chemie (CJY) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A, B: 174 - 326 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 170 | - | expression tag |
| Ser 171 | - | expression tag |
| Met 172 | - | expression tag |
| Asp 173 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35764.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 690.8 | |
| All* | Total formula weight | 36455.6 |
