6B4I

Crystal structure of human Gle1 CTD-Nup42 GBM-DDX19B(ADP) complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (B, A)	Nucleoporin GLE1	polymer	317	36375.1	2	UniProt (Q53GS7) Pfam (PF07817)	Homo sapiens (Human)	hGLE1,GLE1-like protein
2	B, D (C, D)	Nucleoporin like 2	polymer	50	5526.4	2	UniProt (Q3B7J4) UniProt (by SIFTS) (O15504)	Homo sapiens (Human)
3	E, F (E, F)	ATP-dependent RNA helicase DDX19B	polymer	430	48658.0	2	UniProt (Q9UMR2) Pfam (PF00270) Pfam (PF00271)	Homo sapiens (Human)	DEAD box RNA helicase DEAD5,DEAD box protein 19B
4	G, H, J, K, M... (B, A, E, F)	PHOSPHATE ION	non-polymer		95.0	6	Chemie (PO4)
5	I, L (E, F)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)

Sequence modifications

B, A: 383 - 698 (UniProt: Q53GS7)

PDB	External Database	Details
Met 382	-	initiating methionine

C, D: 381 - 423 (UniProt: Q3B7J4)

PDB	External Database	Details
Gly 374	-	expression tag
Pro 375	-	expression tag
Ser 376	-	expression tag
Gly 377	-	expression tag
Ser 378	-	expression tag
Ile 379	-	expression tag
Ile 380	-	expression tag

E, F: 54 - 479 (UniProt: Q9UMR2)

PDB	External Database	Details
Gly 50	-	expression tag
Pro 51	-	expression tag
His 52	-	expression tag
Met 53	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	181119.1
Non-Polymers*	Number of molecules	8
	Total formula weight	1424.2
All*	Total formula weight	182543.4

*Water molecules are not included.