6B3E
Crystal structure of human CDK12/CyclinK in complex with an inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Cyclin-dependent kinase 12 | polymer | 320 | 37128.0 | 2 | UniProt (Q9NYV4) Pfam (PF00069) | Homo sapiens (Human) | Cdc2-related kinase,arginine/serine-rich,CrkRS,Cell division cycle 2-related protein kinase 7,CDC2-related protein kinase 7,Cell division protein kinase 12,hCDK12 |
| 2 | B, D (B, D) | Cyclin-K | polymer | 267 | 31372.1 | 2 | UniProt (O75909) Pfam (PF00134) Pfam (PF21797) | Homo sapiens (Human) | |
| 3 | E, I (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | F, K (A, C) | 2-[(2S)-1-(6-{[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]amino}-9-ethyl-9H-purin-2-yl)piperidin-2-yl]ethan-1-ol | non-polymer | 456.5 | 2 | Chemie (CJM) | |||
| 5 | G, H, J (B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | L, M, N (A, B, D) | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 137000.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1147.8 | |
| All* | Total formula weight | 138148.0 |
