6B1U
Structure of full-length human AMPK (a2b1g1) in complex with a small molecule activator SC4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | polymer | 565 | 63918.1 | 2 | UniProt (P54646) Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) | Homo sapiens (Human) | AMPK subunit alpha-2,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase |
| 2 | B, D (B, D) | 5'-AMP-activated protein kinase subunit beta-1 | polymer | 270 | 30504.3 | 2 | UniProt (Q9Y478) Pfam (PF16561) Pfam (PF04739) | Homo sapiens (Human) | AMPKb |
| 3 | E, F (E, F) | 5'-AMP-activated protein kinase subunit gamma-1 | polymer | 336 | 38225.9 | 2 | UniProt (P54619) Pfam (PF00571) | Homo sapiens (Human) | AMPKg |
| 4 | G, I (A, C) | STAUROSPORINE | non-polymer | 466.5 | 2 | Chemie (STU) | |||
| 5 | H, J (A, C) | 5-{[6-chloro-5-(2'-hydroxy[1,1'-biphenyl]-4-yl)-1H-imidazo[4,5-b]pyridin-2-yl]oxy}-2-methylbenzoic acid | non-polymer | 471.9 | 2 | Chemie (CG7) | |||
| 6 | K (C) | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 7 | L, M, N, O (E, F) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 4 | Chemie (AMP) | |||
| 8 | P, Q, R, S, T... (A, B, C, D, E...) | water | water | 18.0 | 171 | Chemie (HOH) |
Sequence modifications
A, C: 2 - 546 (UniProt: P54646)
E, F: 2 - 331 (UniProt: P54619)
| PDB | External Database | Details |
|---|---|---|
| Met -12 | - | initiating methionine |
| Gly -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Ser -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Gly 271 | Asp 271 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Ala -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Asn 0 | - | expression tag |
| Trp 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 265296.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 3334.8 | |
| All* | Total formula weight | 268631.3 |
