6B19

Architecture of HIV-1 reverse transcriptase initiation complex core

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	reverse transcriptase p66 subunit	polymer	570	65558.3	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075)	Human immunodeficiency virus 1 (HIV-1)
2	B (B)	reverse transcriptase p51 subunit	polymer	442	51585.3	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815)	Human immunodeficiency virus 1 (HIV-1)
3	C (C)	RNA genome fragment	polymer	101	32623.5	1	GenBank (60651827)	Human immunodeficiency virus 1
4	D (D)	tRNA lysine3	polymer	77	24720.7	1		Homo sapiens

Sequence modifications

A: 1 - 560 (UniProt: P03366)

PDB	External Database	Details
Met -1	-	expression tag
Val 0	-	expression tag
Cys 258	Gln 857	engineered mutation
Ser 280	Cys 879	engineered mutation
Gln 478	Glu 1077	engineered mutation
Asp 561	-	expression tag
Leu 562	-	expression tag
Gly 563	-	expression tag
Thr 564	-	expression tag
Leu 565	-	expression tag
Val 566	-	expression tag
Pro 567	-	expression tag
Arg 568	-	expression tag

B: 1 - 440 (UniProt: P03366)

PDB	External Database	Details
Met -1	-	expression tag
Val 0	-	expression tag
Ser 280	Cys 879	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	174487.8
All*	Total formula weight	174487.8

*Water molecules are not included.