6AZL

Structure of cetuximab with aminoheptanoic acid-linked N-carboxyethylarginine meditope variant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	cetuximab Fab light chain	polymer	213	23287.7	2	UniProt (P01834) Pfam (PF07654)	Mus musculus
2	B, D (B, D)	cetuximab Fab heavy chain	polymer	221	23725.5	2	UniProt (S6B291) Pfam (PF07686) Pfam (PF07654)	Mus musculus
3	E, F (E, F)	meditope	polymer	11	1464.7	2		synthetic construct
4	G, H, I (A, C)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
5	J, K, L, M, N... (A, B, C, D, E...)	water	water		18.0	431	Chemie (HOH)

Sequence modifications

A, C: 1 - 107 (PDB: 6AZL)
A, C: 108 - 213 (UniProt: P01834)

PDB	External Database	Details
Ala 213	Glu 106	conflict

B, D: 1 - 107 (PDB: 6AZL)
B, D: 108 - 221 (UniProt: S6B291)

PDB	External Database	Details
Ala 119	Ser 136	conflict

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	96955.8
Non-Polymers*	Number of molecules	3
	Total formula weight	288.2
All*	Total formula weight	97244.0

*Water molecules are not included.