6AZK

Structure of cetuximab with aminoheptanoic acid-linked N-(3-hydroxypropyl)-L-arginine meditope variant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	cetuximab Fab light chain	polymer	213	23287.7	2	UniProt (P01834) Pfam (PF07654) In PDB	Mus musculus
2	B, D	cetuximab Fab heavy chain	polymer	221	23725.5	2	UniProt (S6B291) Pfam (PF07686) Pfam (PF07654) In PDB	Mus musculus
3	E, F	meditope	polymer	11	1450.7	2		synthetic construct
4	B, C	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5		water	water		18.0	526	Chemie (HOH)

Sequence modifications

A, C: 1 - 107 (PDB: 6AZK)
A, C: 108 - 213 (UniProt: P01834)

PDB	External Database	Details
Ala 213	Glu 106	conflict

B, D: 1 - 107 (PDB: 6AZK)
B, D: 108 - 221 (UniProt: S6B291)

PDB	External Database	Details
Ala 119	Ser 136	conflict

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	96927.9
Non-Polymers*	Number of molecules	2
	Total formula weight	192.1
All*	Total formula weight	97120.0

*Water molecules are not included.