6AYD

Pim1 complexed with N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)cyclopropanecarboxamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine/threonine-protein kinase pim-1	polymer	334	38062.1	1	UniProt (P11309) Pfam (PF00069) In PDB	Homo sapiens (Human)
2	A	N-[6-(4-hydroxyphenyl)-2H-indazol-3-yl]cyclopropanecarboxamide	non-polymer		293.3	1	Chemie (C2J)
3		water	water		18.0	34	Chemie (HOH)

Sequence modifications

A: 1 - 312 (UniProt: P11309)

PDB	External Database	Details
Met -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag
Gly 250	Arg 250	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38062.1
Non-Polymers*	Number of molecules	1
	Total formula weight	293.3
All*	Total formula weight	38355.5

*Water molecules are not included.