6AWO
X-ray structure of the ts3 human serotonin transporter complexed with sertraline at the central site
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Sodium-dependent serotonin transporter | polymer | 549 | 61689.8 | 1 | UniProt (P31645) Pfam (PF00209) In PDB | Homo sapiens (Human) | SERT,5HT transporter,5HTT,Solute carrier family 6 member 4 |
2 | B | 8B6 antibody FAB heavy chain | polymer | 229 | 24853.6 | 1 | UniProt (A0A0F7R1P3) Pfam (PF07686) Pfam (PF07654) In PDB | Mus musculus (Mouse) | |
3 | C | 8B6 antibody FAB light chain | polymer | 214 | 23718.2 | 1 | UniProt (A0A0F7R5U8) Pfam (PF07686) Pfam (PF07654) In PDB | Mus musculus (Mouse) | |
4 | A | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine | non-polymer | 306.2 | 1 | Chemie (SRE) | |||
5 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
6 | A | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
7 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
8 | A | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
9 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 76 - 618 (UniProt: P31645)
B: 20 - 138 (PDB: 6AWO)
B: 139 - 237 (UniProt: A0A0F7R1P3)
C: 21 - 116 (PDB: 6AWO)
C: 117 - 234 (UniProt: A0A0F7R5U8)
PDB | External Database | Details |
---|---|---|
Gly 74 | - | expression tag |
Ser 75 | - | expression tag |
Ala 110 | Tyr 110 | engineered mutation |
Ala 291 | Ile 291 | engineered mutation |
Ser 439 | Thr 439 | engineered mutation |
Ala 554 | Cys 554 | engineered mutation |
Ala 580 | Cys 580 | engineered mutation |
Leu 619 | - | expression tag |
Val 620 | - | expression tag |
Pro 621 | - | expression tag |
Arg 622 | - | expression tag |
B: 139 - 237 (UniProt: A0A0F7R1P3)
PDB | External Database | Details |
---|---|---|
Arg 238 | - | expression tag |
Gly 239 | - | expression tag |
Ser 240 | - | expression tag |
His 241 | - | expression tag |
His 242 | - | expression tag |
His 243 | - | expression tag |
His 244 | - | expression tag |
His 245 | - | expression tag |
His 246 | - | expression tag |
His 247 | - | expression tag |
His 248 | - | expression tag |
C: 117 - 234 (UniProt: A0A0F7R5U8)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 110261.6 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1216.7 | |
All* | Total formula weight | 111478.3 |