6AWO
X-ray structure of the ts3 human serotonin transporter complexed with sertraline at the central site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium-dependent serotonin transporter | polymer | 549 | 61689.8 | 1 | UniProt (P31645) Pfam (PF00209) | Homo sapiens (Human) | SERT,5HT transporter,5HTT,Solute carrier family 6 member 4 |
| 2 | B (B) | 8B6 antibody FAB heavy chain | polymer | 229 | 24853.6 | 1 | UniProt (A0A0F7R1P3) | Mus musculus (Mouse) | |
| 3 | C (C) | 8B6 antibody FAB light chain | polymer | 214 | 23718.2 | 1 | UniProt (A0A0F7R5U8) | Mus musculus (Mouse) | |
| 4 | D (A) | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine | non-polymer | 306.2 | 1 | Chemie (SRE) PubChem (18647614) PubChem (5203) PubChem (22840180) PubChem (54375) PubChem (68617) PubChem (54390675) PubChem (6093397) PubChem (9882979) PubChem (13408686) | |||
| 5 | E, G (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | F (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (45044259) PubChem (23423981) PubChem (49853509) PubChem (50990013) PubChem (52934537) PubChem (56621683) PubChem (191463) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (368063) PubChem (369319) PubChem (44654663) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (46937002) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (638019) PubChem (59274407) PubChem (1549081) PubChem (1553803) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (89951918) PubChem (90224410) PubChem (5997) PubChem (5283629) PubChem (5284644) PubChem (1551269) PubChem (90070115) PubChem (91298236) PubChem (5315842) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (6419195) PubChem (10861996) PubChem (132837164) PubChem (101624109) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (124225449) PubChem (138967089) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (139566851) PubChem (124429284) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (15939944) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (171828367) PubChem (173516975) PubChem (130459183) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 7 | H (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 8 | I, J (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) PubChem (923) | |||
| 9 | K (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 76 - 618 (UniProt: P31645)
B: 20 - 138 (PDB: 6AWO)
B: 139 - 237 (UniProt: A0A0F7R1P3)
C: 21 - 116 (PDB: 6AWO)
C: 117 - 234 (UniProt: A0A0F7R5U8)
| PDB | External Database | Details |
|---|---|---|
| Gly 74 | - | expression tag |
| Ser 75 | - | expression tag |
| Ala 110 | Tyr 110 | engineered mutation |
| Ala 291 | Ile 291 | engineered mutation |
| Ser 439 | Thr 439 | engineered mutation |
| Ala 554 | Cys 554 | engineered mutation |
| Ala 580 | Cys 580 | engineered mutation |
| Leu 619 | - | expression tag |
| Val 620 | - | expression tag |
| Pro 621 | - | expression tag |
| Arg 622 | - | expression tag |
B: 139 - 237 (UniProt: A0A0F7R1P3)
| PDB | External Database | Details |
|---|---|---|
| Arg 238 | - | expression tag |
| Gly 239 | - | expression tag |
| Ser 240 | - | expression tag |
| His 241 | - | expression tag |
| His 242 | - | expression tag |
| His 243 | - | expression tag |
| His 244 | - | expression tag |
| His 245 | - | expression tag |
| His 246 | - | expression tag |
| His 247 | - | expression tag |
| His 248 | - | expression tag |
C: 117 - 234 (UniProt: A0A0F7R5U8)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 110261.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1216.7 | |
| All* | Total formula weight | 111478.3 |
