6AVR
Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody LM609
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Integrin alpha-V | polymer | 957 | 105894.2 | 1 | UniProt (P06756) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF20806) In PDB | Homo sapiens (Human) | Vitronectin receptor,Vitronectin receptor subunit alpha |
2 | B | Integrin beta-3 | polymer | 692 | 76523.1 | 1 | UniProt (P05106) Pfam (PF07974) Pfam (PF07965) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) In PDB | Homo sapiens (Human) | Platelet membrane glycoprotein IIIa,GPIIIa |
3 | H | Fab LM609 heavy chain | polymer | 257 | 27223.1 | 1 | Mus musculus | ||
4 | L | Fab LM609 light chain | polymer | 214 | 23629.0 | 1 | Mus musculus |
Sequence modifications
A: 1 - 957 (UniProt: P06756)
PDB | External Database | Details |
---|---|---|
Ile 753 | Val 783 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 233269.4 | |
All* | Total formula weight | 233269.4 |