6AU2
Crystal structure of SETDB1 Tudor domain with aryl triazole fragments
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase SETDB1 | polymer | 213 | 24887.8 | 1 | UniProt (Q15047) Pfam (PF18300) Pfam (PF18359) Pfam (PF18358) | Homo sapiens (Human) | ERG-associated protein with SET domain,ESET,Histone H3-K9 methyltransferase 4,H3-K9-HMTase 4,Lysine N-methyltransferase 1E,SET domain bifurcated 1 |
| 2 | B (A) | 1-methyl-4H,6H-[1,2,4]triazolo[4,3-a][4,1]benzoxazepine | non-polymer | 201.2 | 1 | Chemie (CGJ) | |||
| 3 | C, D (A) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 2 | Chemie (BME) | |||
| 4 | E, F, G, H, I (A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | J, K, L, M, N... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 6 | AA, BA, P, Q, R... (A) | UNKNOWN ATOM OR ION | non-polymer | 13 | Chemie (UNX) | ||||
| 7 | CA (A) | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence modifications
A: 196 - 402 (UniProt: Q15047)
| PDB | External Database | Details |
|---|---|---|
| Glu 190 | - | expression tag |
| Asn 191 | - | expression tag |
| Leu 192 | - | expression tag |
| Tyr 193 | - | expression tag |
| Phe 194 | - | expression tag |
| Gln 195 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24887.8 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 1210.2 | |
| All* | Total formula weight | 26098.0 |
