6AQO
Crystal structure of hypoxanthine-guanine-xanthine phosphorybosyltranferase in complex with {[(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 272 | 30655.0 | 6 | UniProt (Q38CA1) Pfam (PF00156) In PDB | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) | |
2 | A, B, C, D, E... | {[(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid) | non-polymer | 441.3 | 6 | Chemie (45T) | |||
3 | D, E | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 2 - 234 (UniProt: Q38CA1)
PDB | External Database | Details |
---|---|---|
Met -37 | - | initiating methionine |
Gly -36 | - | expression tag |
Ser -35 | - | expression tag |
Ser -34 | - | expression tag |
His -33 | - | expression tag |
His -32 | - | expression tag |
His -31 | - | expression tag |
His -30 | - | expression tag |
His -29 | - | expression tag |
His -28 | - | expression tag |
Asp -27 | - | expression tag |
Tyr -26 | - | expression tag |
Asp -25 | - | expression tag |
Ile -24 | - | expression tag |
Pro -23 | - | expression tag |
Thr -22 | - | expression tag |
Thr -21 | - | expression tag |
Glu -20 | - | expression tag |
Asn -19 | - | expression tag |
Leu -18 | - | expression tag |
Tyr -17 | - | expression tag |
Phe -16 | - | expression tag |
Gln -15 | - | expression tag |
Gly -14 | - | expression tag |
His -13 | - | expression tag |
Met -12 | - | expression tag |
Ala -11 | - | expression tag |
Ser -10 | - | expression tag |
Met -9 | - | expression tag |
Thr -8 | - | expression tag |
Gly -7 | - | expression tag |
Gly -6 | - | expression tag |
Gln -5 | - | expression tag |
Gln -4 | - | expression tag |
Met -3 | - | expression tag |
Gly -2 | - | expression tag |
Arg -1 | - | expression tag |
Gly 0 | - | expression tag |
Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 183930.0 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2696.2 | |
All* | Total formula weight | 186626.2 |