6AQO
Crystal structure of hypoxanthine-guanine-xanthine phosphorybosyltranferase in complex with {[(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 272 | 30655.0 | 6 | UniProt (Q38CA1) Pfam (PF00156) | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) | |
| 2 | G, H, I, J, L... (A, B, C, D, E...) | {[(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid) | non-polymer | 441.3 | 6 | Chemie (45T) | |||
| 3 | K, M (D, E) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | O, P, Q, R, S... (A, B, C, D, E...) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 2 - 234 (UniProt: Q38CA1)
| PDB | External Database | Details |
|---|---|---|
| Met -37 | - | initiating methionine |
| Gly -36 | - | expression tag |
| Ser -35 | - | expression tag |
| Ser -34 | - | expression tag |
| His -33 | - | expression tag |
| His -32 | - | expression tag |
| His -31 | - | expression tag |
| His -30 | - | expression tag |
| His -29 | - | expression tag |
| His -28 | - | expression tag |
| Asp -27 | - | expression tag |
| Tyr -26 | - | expression tag |
| Asp -25 | - | expression tag |
| Ile -24 | - | expression tag |
| Pro -23 | - | expression tag |
| Thr -22 | - | expression tag |
| Thr -21 | - | expression tag |
| Glu -20 | - | expression tag |
| Asn -19 | - | expression tag |
| Leu -18 | - | expression tag |
| Tyr -17 | - | expression tag |
| Phe -16 | - | expression tag |
| Gln -15 | - | expression tag |
| Gly -14 | - | expression tag |
| His -13 | - | expression tag |
| Met -12 | - | expression tag |
| Ala -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Met -9 | - | expression tag |
| Thr -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gln -4 | - | expression tag |
| Met -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Arg -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 183930.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2696.2 | |
| All* | Total formula weight | 186626.2 |
