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6APU

Crystal structure of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltranferase in complex with (2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](3-aminopropyl)amino}ethyl)phosphonic acid

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Hypoxanthine-guanine phosphoribosyltransferasepolymer21624221.82UniProt (Q07010)
Pfam (PF00156)
Trypanosoma brucei bruceiHGPRTase
2C, J
(A, B)
SULFATE IONnon-polymer96.12Chemie (SO4)
3D, E, F, G, K...
(A, B)
MAGNESIUM IONnon-polymer24.36Chemie (MG)
4H, M
(A, B)
DI(HYDROXYETHYL)ETHERnon-polymer106.12Chemie (PEG)
5I, N
(A, B)
(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](3-aminopropyl)amino}ethyl)phosphonic acidnon-polymer359.32Chemie (3L6)
6O, P
(A, B)
waterwater18.0428Chemie (HOH)
Sequence modifications
A, B: 1 - 210 (UniProt: Q07010)
PDBExternal DatabaseDetails
His -5-expression tag
His -4-expression tag
His -3-expression tag
His -2-expression tag
His -1-expression tag
His 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight48443.6
Non-Polymers*Number of molecules12
Total formula weight1268.8
All*Total formula weight49712.4
*Water molecules are not included.

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PDB entries from 2025-07-09

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