6APU

Crystal structure of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltranferase in complex with (2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](3-aminopropyl)amino}ethyl)phosphonic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Hypoxanthine-guanine phosphoribosyltransferase	polymer	216	24221.8	2	UniProt (Q07010) Pfam (PF00156)	Trypanosoma brucei brucei	HGPRTase
2	C, J (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	D, E, F, G, K... (A, B)	MAGNESIUM ION	non-polymer		24.3	6	Chemie (MG)
4	H, M (A, B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
5	I, N (A, B)	(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](3-aminopropyl)amino}ethyl)phosphonic acid	non-polymer		359.3	2	Chemie (3L6)
6	O, P (A, B)	water	water		18.0	428	Chemie (HOH)

Sequence modifications

A, B: 1 - 210 (UniProt: Q07010)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	48443.6
Non-Polymers*	Number of molecules	12
	Total formula weight	1268.8
All*	Total formula weight	49712.4

*Water molecules are not included.