6AOH

Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-2533)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Bifunctional dihydrofolate reductase-thymidylate synthase	polymer	566	64214.3	2	UniProt (Q07422) Pfam (PF00186) Pfam (PF00303) In PDB	Toxoplasma gondii	DHFR-TS
2	A, B	2'-DEOXYURIDINE 5'-MONOPHOSPHATE	non-polymer		308.2	2	Chemie (UMP)
3	A, B	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
4	A, B	10-PROPARGYL-5,8-DIDEAZAFOLIC ACID	non-polymer		477.5	2	Chemie (CB3)
5	A, B	5-{4-[3-(2-methoxypyrimidin-5-yl)phenyl]piperazin-1-yl}pyrimidine-2,4-diamine	non-polymer		378.4	2	Chemie (BOD)

Sequence modifications

A, B: 1 - 72 (UniProt: Q07422)
A, B: 73 - 219 (UniProt: Q07422)
A, B: 220 - 610 (UniProt: Q07422)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	128428.6
Non-Polymers*	Number of molecules	8
	Total formula weight	3819.0
All*	Total formula weight	132247.6

*Water molecules are not included.