6AOH
Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-2533)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 566 | 64214.3 | 2 | UniProt (Q07422) Pfam (PF00186) Pfam (PF00303) In PDB | Toxoplasma gondii | DHFR-TS |
2 | A, B | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 2 | Chemie (UMP) | |||
3 | A, B | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
4 | A, B | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID | non-polymer | 477.5 | 2 | Chemie (CB3) | |||
5 | A, B | 5-{4-[3-(2-methoxypyrimidin-5-yl)phenyl]piperazin-1-yl}pyrimidine-2,4-diamine | non-polymer | 378.4 | 2 | Chemie (BOD) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 128428.6 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 3819.0 | |
All* | Total formula weight | 132247.6 |