6AOG

Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine (pyrimethamine)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Bifunctional dihydrofolate reductase-thymidylate synthase	polymer	566	64214.3	2	UniProt (Q07422) Pfam (PF00186) Pfam (PF00303)	Toxoplasma gondii	DHFR-TS
2	C, G (A, B)	2'-DEOXYURIDINE 5'-MONOPHOSPHATE	non-polymer		308.2	2	Chemie (UMP)
3	D, H (A, B)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
4	E, I (A, B)	10-PROPARGYL-5,8-DIDEAZAFOLIC ACID	non-polymer		477.5	2	Chemie (CB3)
5	F, J (A, B)	5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE	non-polymer		248.7	2	Chemie (CP6)

Sequence modifications

A, B: 1 - 72 (UniProt: Q07422)
A, B: 73 - 219 (UniProt: Q07422)
A, B: 220 - 610 (UniProt: Q07422)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	128428.6
Non-Polymers*	Number of molecules	8
	Total formula weight	3559.6
All*	Total formula weight	131988.2

*Water molecules are not included.