6ALE
A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Small conductance calcium-activated potassium channel protein 2 | polymer | 95 | 11331.4 | 1 | UniProt (Q9H2S1) Pfam (PF02888) | Homo sapiens (Human) | SKCa2,KCa2.2 |
| 2 | B (R) | Calmodulin-2 | polymer | 146 | 16420.0 | 1 | UniProt (P0DP30) Pfam (PF13499) | Rattus norvegicus (Rat) | |
| 3 | C, D, E, J (B, R) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | F (B) | (3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one | non-polymer | 231.0 | 1 | Chemie (1KP) | |||
| 5 | G (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | H, I (R) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 7 | K, L (B, R) | water | water | 18.0 | 116 | Chemie (HOH) |
Sequence modifications
B: 395 - 487 (UniProt: Q9H2S1)
R: 4 - 147 (UniProt: P0DP30)
| PDB | External Database | Details |
|---|---|---|
| Gly 395 | Ala 394 | conflict |
| Phe 407 | Val 406 | conflict |
| Leu 488 | - | expression tag |
| Glu 489 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 2 | - | expression tag |
| Ala 3 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27751.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 787.5 | |
| All* | Total formula weight | 28538.9 |
