6AAM
Crystal structure of TYK2 in complex with peficitinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Non-receptor tyrosine-protein kinase TYK2 | polymer | 298 | 34011.9 | 1 | UniProt (P29597) Pfam (PF07714) | Homo sapiens (Human) | |
| 2 | B (A) | 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide | non-polymer | 326.4 | 1 | Chemie (9T6) | |||
| 3 | C (A) | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A: 888 - 1182 (UniProt: P29597)
| PDB | External Database | Details |
|---|---|---|
| Gly 885 | - | expression tag |
| Pro 886 | - | expression tag |
| Gly 887 | - | expression tag |
| Ala 936 | Cys 936 | engineered mutation |
| Ala 969 | Gln 969 | engineered mutation |
| Ala 971 | Glu 971 | engineered mutation |
| Ala 972 | Lys 972 | engineered mutation |
| Asn 1023 | Asp 1023 | engineered mutation |
| Leu 1114 | Ile 1114 | engineered mutation |
| Ala 1142 | Cys 1142 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34011.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 326.4 | |
| All* | Total formula weight | 34338.3 |
