6AAJ
Crystal structure of JAK2 in complex with peficitinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Tyrosine-protein kinase JAK2 | polymer | 299 | 35138.8 | 2 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
| 2 | A, B | 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide | non-polymer | 326.4 | 2 | Chemie (9T6) | |||
| 3 | water | water | 18.0 | 42 | Chemie (HOH) |
Sequence modifications
A, B: 834 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Ala 943 | Lys 943 | engineered mutation |
| Ala 945 | Lys 945 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70277.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 652.8 | |
| All* | Total formula weight | 70930.5 |
