6A1G
Crystal structure of human DYRK1A in complex with compound 32
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 360 | 41904.4 | 2 | UniProt (Q13627) Pfam (PF00069) | Homo sapiens (Human) | Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,hMNB |
| 2 | C, D (A, B) | 5,5-dimethyl-8-[1-(piperidin-4-yl)ethenyl]-5,6-dihydrobenzo[h]quinazolin-4-amine | non-polymer | 334.5 | 2 | Chemie (9OL) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A, B: 127 - 483 (UniProt: Q13627)
| PDB | External Database | Details |
|---|---|---|
| Gly 124 | - | expression tag |
| Pro 125 | - | expression tag |
| Met 126 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 83808.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 668.9 | |
| All* | Total formula weight | 84477.8 |
