5ZZ4
Crystal structure of bruton's tyrosine kinase in complex with inhibitor 2e
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | Tyrosine-protein kinase BTK | polymer | 268 | 31178.9 | 6 | UniProt (Q06187) Pfam (PF07714) In PDB | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | A, B, C, D, E... | N-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide | non-polymer | 565.7 | 6 | Chemie (9M3) |
Sequence modifications
A, B, C, D, E, F: 393 - 656 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Gly 389 | - | expression tag |
| Ala 390 | - | expression tag |
| Met 391 | - | expression tag |
| Gly 392 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 187073.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3394.0 | |
| All* | Total formula weight | 190467.5 |
