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5ZYA

SF3b spliceosomal complex bound to E7107

Replaces:  5ZD5
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(B)
Splicing factor 3B subunit 5polymer8610149.41UniProt (Q9BWJ5)
Pfam (PF07189)
Homo sapiens (Human)SF3b5
2B
(C)
Splicing factor 3B subunit 1polymer1304146024.91UniProt (O75533)
Pfam (PF08920)
Pfam (PF22646)
Homo sapiens (Human)Pre-mRNA-splicing factor SF3b 155 kDa subunit,SF3b155
3C
(D)
PHD finger-like domain-containing protein 5Apolymer859395.01UniProt (Q7RTV0)
Pfam (PF03660)
Homo sapiens (Human)PHD finger-like domain protein 5A
4D
(A)
Splicing factor 3B subunit 3polymer1223136471.61UniProt (Q15393)
Pfam (PF10433)
Pfam (PF03178)
Homo sapiens (Human)Pre-mRNA-splicing factor SF3b 130 kDa subunit,SF3b130
5E
(C)
[(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{R})-6-methyl-6-oxidanyl-7-[(2~{R},3~{R})-3-[(2~{R},3~{S})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] 4-cycloheptylpiperazine-1-carboxylatenon-polymer719.01Chemie (9B0)
6F, G, H
(D)
ZINC IONnon-polymer65.43Chemie (ZN)
7I
(A)
POTASSIUM IONnon-polymer39.11Chemie (K)
Sequence modifications
A: 1 - 1217 (UniProt: Q15393)
PDBExternal DatabaseDetails
Asp 0-expression tag
Asp 1218-expression tag
Tyr 1219-expression tag
Lys 1220-expression tag
Asp 1221-expression tag
Asp 1222-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight302040.8
Non-Polymers*Number of molecules5
Total formula weight954.3
All*Total formula weight302995.1
*Water molecules are not included.

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PDB entries from 2024-10-30

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