5ZUJ

Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	TNF receptor-associated factor 6	polymer	161	18857.8	1	UniProt (Q9Y4K3) Pfam (PF21355)	Homo sapiens (Human)	E3 ubiquitin-protein ligase TRAF6,Interleukin-1 signal transducer,RING finger protein 85,RING-type E3 ubiquitin transferase TRAF6
2	B (I)	peptide 170-184 from TRAF-interacting protein with FHA domain-containing protein A	polymer	15	1639.5	1	UniProt (Q96CG3)	Homo sapiens	TRAF2-binding protein
3	C, D (A, I)	water	water		18.0	63	Chemie (HOH)

Sequence modifications

A: 350 - 501 (UniProt: Q9Y4K3)

PDB	External Database	Details
Met 349	-	expression tag
Leu 502	-	expression tag
Glu 503	-	expression tag
His 504	-	expression tag
His 505	-	expression tag
His 506	-	expression tag
His 507	-	expression tag
His 508	-	expression tag
His 509	-	expression tag

I: 170 - 184 (UniProt: Q96CG3)

PDB	External Database	Details
Gln 174	Ser 174	engineered mutation
Asp 179	Met 179	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	20497.3
All*	Total formula weight	20497.3

*Water molecules are not included.