5ZTO
Crystal structure of EGFR 696-1022 T790M/C797S in complex with D3003
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 331 | 37634.5 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | A | N-{trans-4-[3-(2-chlorophenyl)-7-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]cyclohexyl}propanamide | non-polymer | 617.2 | 1 | Chemie (9JO) | |||
3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
4 | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence modifications
A: 696 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 692 | - | expression tag |
Ala 693 | - | expression tag |
Met 694 | - | expression tag |
Gly 695 | - | expression tag |
Met 790 | Thr 790 | engineered mutation |
Ser 797 | Cys 797 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37634.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 652.6 | |
All* | Total formula weight | 38287.2 |