5ZSN
Crystal structure of monkey TLR7 in complex with AAUUAA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Toll-like receptor 7 | polymer | 823 | 94745.6 | 2 | UniProt (B3Y653) Pfam (PF13855) | Macaca mulatta (Rhesus macaque) | |
| 2 | C, D (D, E) | RNA (5'-R(P*UP*UP*AP*A)-3') | polymer | 6 | 1884.2 | 2 | synthetic construct | ||
| 3 | E, G (C, G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 4 | F (F) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 383.3 | 1 | In PDB GlyTouCan (G90333CG) | |||
| 5 | AA, BA, H, I, J... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) | |||
| 6 | CA, O (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 7 | DA, EA, FA, P, Q... (A, B) | SULFATE ION | non-polymer | 96.1 | 13 | Chemie (SO4) | |||
| 8 | GA, Z (A, B) | 2',3'- cyclic AMP | non-polymer | 329.2 | 2 | Chemie (ACK) | |||
| 9 | HA, IA (B, A) | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
B, A: 27 - 839 (UniProt: B3Y653)
| PDB | External Database | Details |
|---|---|---|
| Arg 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Pro 25 | - | expression tag |
| Trp 26 | - | expression tag |
| Gln 167 | Asn 167 | engineered mutation |
| Gln 389 | Asn 389 | engineered mutation |
| Leu 440 | Ser 440 | see sequence details |
| Val 441 | Glu 441 | see sequence details |
| Pro 442 | Val 442 | see sequence details |
| Arg 443 | Gly 443 | see sequence details |
| Gly 444 | Phe 444 | see sequence details |
| Ser 445 | Cys 445 | see sequence details |
| Gln 488 | Asn 488 | engineered mutation |
| Gln 799 | Asn 799 | engineered mutation |
| Glu 840 | - | expression tag |
| Phe 841 | - | expression tag |
| Leu 842 | - | expression tag |
| Val 843 | - | expression tag |
| Pro 844 | - | expression tag |
| Arg 845 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 193259.6 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1232.2 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 4088.0 | |
| All* | Total formula weight | 198579.8 |
