5ZSB
Crystal structure of monkey TLR7 in complex with IMDQ and AAUUAA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Toll-like receptor 7 | polymer | 823 | 94745.6 | 2 | UniProt (B3Y653) Pfam (PF13855) In PDB | Macaca mulatta (Rhesus macaque) | |
2 | C, D | RNA (5'-R(*AP*UP*UP*AP*A)-3') | polymer | 6 | 1884.2 | 2 | synthetic construct | ||
3 | E, F, G | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 11 | Chemie (NAG) | |||
5 | A, B | 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine | non-polymer | 359.5 | 2 | Chemie (IDQ) | |||
6 | A, B | SULFATE ION | non-polymer | 96.1 | 13 | Chemie (SO4) | |||
7 | water | water | 18.0 | 188 | Chemie (HOH) |
Sequence modifications
B, A: 27 - 839 (UniProt: B3Y653)
PDB | External Database | Details |
---|---|---|
Arg 23 | - | expression tag |
Ser 24 | - | expression tag |
Pro 25 | - | expression tag |
Trp 26 | - | expression tag |
Gln 167 | Asn 167 | engineered mutation |
Gln 389 | Asn 389 | engineered mutation |
Leu 440 | Ser 440 | see sequence details |
Val 441 | Glu 441 | see sequence details |
Pro 442 | Val 442 | see sequence details |
Arg 443 | Gly 443 | see sequence details |
Gly 444 | Phe 444 | see sequence details |
Ser 445 | Cys 445 | see sequence details |
Gln 488 | Asn 488 | engineered mutation |
Gln 799 | Asn 799 | engineered mutation |
Glu 840 | - | expression tag |
Phe 841 | - | expression tag |
Leu 842 | - | expression tag |
Val 843 | - | expression tag |
Pro 844 | - | expression tag |
Arg 845 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 193259.6 | |
Branched | Number of molecules | 3 |
Total formula weight | 1273.2 | |
Non-Polymers* | Number of molecules | 26 |
Total formula weight | 4401.0 | |
All* | Total formula weight | 198933.8 |