5ZSB

Crystal structure of monkey TLR7 in complex with IMDQ and AAUUAA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	Toll-like receptor 7	polymer	823	94745.6	2	UniProt (B3Y653) Pfam (PF13855) In PDB	Macaca mulatta (Rhesus macaque)
2	C, D	RNA (5'-R(*AP*UP*UP*AP*A)-3')	polymer	6	1884.2	2		synthetic construct
3	E, F, G	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
4	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	11	Chemie (NAG)
5	A, B	1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine	non-polymer		359.5	2	Chemie (IDQ)
6	A, B	SULFATE ION	non-polymer		96.1	13	Chemie (SO4)
7		water	water		18.0	188	Chemie (HOH)

Sequence modifications

B, A: 27 - 839 (UniProt: B3Y653)

PDB	External Database	Details
Arg 23	-	expression tag
Ser 24	-	expression tag
Pro 25	-	expression tag
Trp 26	-	expression tag
Gln 167	Asn 167	engineered mutation
Gln 389	Asn 389	engineered mutation
Leu 440	Ser 440	see sequence details
Val 441	Glu 441	see sequence details
Pro 442	Val 442	see sequence details
Arg 443	Gly 443	see sequence details
Gly 444	Phe 444	see sequence details
Ser 445	Cys 445	see sequence details
Gln 488	Asn 488	engineered mutation
Gln 799	Asn 799	engineered mutation
Glu 840	-	expression tag
Phe 841	-	expression tag
Leu 842	-	expression tag
Val 843	-	expression tag
Pro 844	-	expression tag
Arg 845	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	193259.6
Branched	Number of molecules	3
	Total formula weight	1273.2
Non-Polymers*	Number of molecules	26
	Total formula weight	4401.0
All*	Total formula weight	198933.8

*Water molecules are not included.