5ZRX

Crystal Structure of EphA2/SHIP2 Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2,Ephrin type-A receptor 2	polymer	159	17621.7	2	UniProt (Q6P549) UniProt (Q03145) Pfam (PF00536)	Mus musculus (Mouse)	AblSH3-binding protein,Inositol polyphosphate phosphatase-like protein 1,INPPL-1,SH2 domain-containing inositol 5'-phosphatase 2,SHIP-2,Epithelial cell kinase,Tyrosine-protein kinase receptor ECK,Tyrosine-protein kinase receptor MPK-5,Tyrosine-protein kinase receptor SEK-2
2	C, D (A, B)	water	water		18.0	273	Chemie (HOH)

Sequence modifications

A, B: 1200 - 1257 (UniProt: Q6P549)

PDB	External Database	Details
Gly 1194	-	expression tag
Pro 1195	-	expression tag
Gly 1196	-	expression tag
Ser 1197	-	expression tag
Glu 1198	-	expression tag
Phe 1199	-	expression tag
Ser 1258	-	linker
Ser 1259	-	linker
Gly 1260	-	linker
Glu 1261	-	linker
Asn 1262	-	linker
Leu 1263	-	linker
Tyr 1264	-	linker
Phe 1265	-	linker
Gln 1266	-	linker
Ser 1267	-	linker
Ser 1268	-	linker
Gly 1269	-	linker
Ser 1270	-	linker
Ser 1271	-	linker
Gly 1272	-	linker
Gly 898	-	linker
Ser 899	-	linker

A, B: 900 - 977 (UniProt: Q03145)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	35243.3
All*	Total formula weight	35243.3

*Water molecules are not included.