5ZR3
Crystal structure of Hsp90-alpha N-terminal domain in complex with 4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3-methylbenzamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, C, E, G) | Heat shock protein HSP 90-alpha | polymer | 237 | 26739.9 | 4 | UniProt (P07900) Pfam (PF13589) | Homo sapiens (Human) | Heat shock 86 kDa,HSP86,Lipopolysaccharide-associated protein 2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38 |
| 2 | E, F, G, H (A, C, E, G) | 3-methyl-4-{4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide | non-polymer | 440.5 | 4 | Chemie (9J0) | |||
| 3 | I, J, K, L (A, C, E, G) | water | water | 18.0 | 102 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 1 - 236 (UniProt: P07900)
| PDB | External Database | Details |
|---|---|---|
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 106959.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1762.0 | |
| All* | Total formula weight | 108721.7 |
