5ZO9
Eg5 motor domain in complex with STLC-type inhibitor PVEI0021 (C2 type)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Kinesin-like protein KIF11 | polymer | 367 | 41300.9 | 2 | UniProt (P52732) Pfam (PF00225) In PDB | Homo sapiens (Human) | Kinesin-like protein 1,Kinesin-like spindle protein HKSP,Kinesin-related motor protein Eg5,Thyroid receptor-interacting protein 5,TRIP-5 |
2 | A, B | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | A, B | (2R)-2-azanyl-3-[(4-methoxyphenyl)-diphenyl-methyl]sulfanyl-propanoic acid | non-polymer | 393.5 | 2 | Chemie (4C5) | |||
5 | A, B | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
6 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
7 | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A, B: 17 - 369 (UniProt: P52732)
PDB | External Database | Details |
---|---|---|
Met 10 | - | expression tag |
Asn 11 | - | expression tag |
His 12 | - | expression tag |
Lys 13 | - | expression tag |
Val 14 | - | expression tag |
His 15 | - | expression tag |
Met 16 | - | expression tag |
Gln 370 | - | expression tag |
His 371 | - | expression tag |
His 372 | - | expression tag |
His 373 | - | expression tag |
His 374 | - | expression tag |
His 375 | - | expression tag |
His 376 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 82601.8 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 2120.2 | |
All* | Total formula weight | 84722.1 |