5ZKI

Human EXOG-H140A in complex with duplex DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F (A, B)	Nuclease EXOG, mitochondrial	polymer	348	39216.3	2	UniProt (Q9Y2C4) Pfam (PF01223) Pfam (PF18026)	Homo sapiens (Human)	Endonuclease G-like 1,Endo G-like 1
2	B, C, D, E (C, D, E, F)	DNA (5'-D(*CP*GP*GP*GP*AP*TP*AP*TP*CP*CP*CP*G)-3')	polymer	12	3663.4	4		synthetic construct
3	G, J (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	H, I, K (C, E, B)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
5	L, M, N, O, P... (A, C, D, E, F...)	water	water		18.0	111	Chemie (HOH)

Sequence modifications

A, B: 42 - 368 (UniProt: Q9Y2C4)

PDB	External Database	Details
Met 21	-	expression tag
Gly 22	-	expression tag
Ser 23	-	expression tag
Ser 24	-	expression tag
His 25	-	expression tag
His 26	-	expression tag
His 27	-	expression tag
His 28	-	expression tag
His 29	-	expression tag
His 30	-	expression tag
Ser 31	-	expression tag
Ser 32	-	expression tag
Gly 33	-	expression tag
Leu 34	-	expression tag
Val 35	-	expression tag
Pro 36	-	expression tag
Arg 37	-	expression tag
Gly 38	-	expression tag
Ser 39	-	expression tag
His 40	-	expression tag
Met 41	-	expression tag
Ala 140	His 140	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	93086.1
Non-Polymers*	Number of molecules	5
	Total formula weight	143.8
All*	Total formula weight	93229.9

*Water molecules are not included.