5ZJW
Crystal Structure of PAK4 in complex with inhibitor CZg353
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase PAK 4 | polymer | 293 | 33098.4 | 1 | UniProt (O96013) Pfam (PF00069) In PDB | Homo sapiens (Human) | p21-activated kinase 4,PAK-4 |
| 2 | A | (3Z)-N-[(1S)-2-hydroxy-1-phenylethyl]-3-[(1H-imidazol-2-yl)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide | non-polymer | 450.5 | 1 | Chemie (9EO) | |||
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 4 | A | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 5 | A | BICARBONATE ION | non-polymer | 61.0 | 1 | Chemie (BCT) | |||
| 6 | water | water | 18.0 | 283 | Chemie (HOH) |
Sequence modifications
A: 300 - 591 (UniProt: O96013)
| PDB | External Database | Details |
|---|---|---|
| Ser 299 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33098.4 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1130.2 | |
| All* | Total formula weight | 34228.6 |
