5ZFB

Structure of human dihydroorotate dehydrogenase in complex with ascofuranone (open-form)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Dihydroorotate dehydrogenase (quinone), mitochondrial	polymer	390	42636.4	1	UniProt (Q02127) Pfam (PF01180)	Homo sapiens (Human)	DHOdehase,Dihydroorotate oxidase
2	B (A)	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	1	Chemie (FMN)
3	C (A)	OROTIC ACID	non-polymer		156.1	1	Chemie (ORO)
4	D (A)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
5	E, F, G, H, I... (A)	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
6	J (A)	3-chloro-4,6-dihydroxy-5-[(2Z,6Z,8E)-11-hydroxy-3,7,11-trimethyl-10-oxododeca-2,6,8-trien-1-yl]-2-methylbenzaldehyde	non-polymer		420.9	1	Chemie (9BX)
7	L (A)	water	water		18.0	183	Chemie (HOH)

Sequence modifications

A: 30 - 396 (UniProt: Q02127)

PDB	External Database	Details
Met 7	-	expression tag
Gly 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
Ser 19	-	expression tag
Ser 20	-	expression tag
Gly 21	-	expression tag
His 22	-	expression tag
Ile 23	-	expression tag
Asp 24	-	expression tag
Asp 25	-	expression tag
Asp 26	-	expression tag
Asp 27	-	expression tag
Lys 28	-	expression tag
His 29	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42636.4
Non-Polymers*	Number of molecules	10
	Total formula weight	1668.8
All*	Total formula weight	44305.2

*Water molecules are not included.