5ZF7

Structure of human dihydroorotate dehydrogenase in complex with 277-9-OH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Dihydroorotate dehydrogenase (quinone), mitochondrial	polymer	390	42636.4	1	UniProt (Q02127) Pfam (PF01180)	Homo sapiens (Human)	DHOdehase,Dihydroorotate oxidase
2	B (A)	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	1	Chemie (FMN)
3	C (A)	OROTIC ACID	non-polymer		156.1	1	Chemie (ORO)
4	D, E (A)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
5	F, G, H (A)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
6	I (A)	3-chloro-4,6-dihydroxy-5-[(2E,6E,8S)-8-hydroxy-3,7-dimethylnona-2,6-dien-1-yl]-2-methylbenzaldehyde	non-polymer		352.9	1	Chemie (CHW)
7	J (A)	water	water		18.0	239	Chemie (HOH)

Sequence modifications

A: 30 - 396 (UniProt: Q02127)

PDB	External Database	Details
Met 7	-	expression tag
Gly 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
Ser 19	-	expression tag
Ser 20	-	expression tag
Gly 21	-	expression tag
His 22	-	expression tag
Ile 23	-	expression tag
Asp 24	-	expression tag
Asp 25	-	expression tag
Asp 26	-	expression tag
Asp 27	-	expression tag
Lys 28	-	expression tag
His 29	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42636.4
Non-Polymers*	Number of molecules	8
	Total formula weight	1371.6
All*	Total formula weight	44008.0

*Water molecules are not included.