5Z8Y

Crystal structure of human LRRTM2 in complex with Neurexin 1beta

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	Leucine-rich repeat transmembrane neuronal protein 2	polymer	346	39723.4	4	UniProt (O43300) Pfam (PF13855)	Homo sapiens (Human)	Leucine-rich repeat neuronal 2 protein
2	B, D, F, H (B, D, F, H)	Neurexin-1-beta	polymer	193	20953.4	4	UniProt (P58400) Pfam (PF02210)	Homo sapiens (Human)	Neurexin I-beta
3	I, J, K, L (I, J, K, L)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	4	In PDB GlyTouCan (G21290RB)
4	AA, BA, CA, M, N... (G, A, C, E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	12	Chemie (NAG)
5	P, U (A, C)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	DA, Q, V, Z (H, B, D, F)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA) PubChem (271)
7	EA, FA, GA, HA (B, C, F, H)	water	water		18.0	4	Chemie (HOH)

Sequence modifications

A, C, E, G: 34 - 371 (UniProt: O43300)

PDB	External Database	Details
Ala 355	His 355	engineered mutation
Gly 372	-	expression tag
Ser 373	-	expression tag
His 374	-	expression tag
His 375	-	expression tag
His 376	-	expression tag
His 377	-	expression tag
His 378	-	expression tag
His 379	-	expression tag

B, D, F, H: 86 - 266 (UniProt: P58400)

PDB	External Database	Details
Asp 82	-	expression tag
Ala 83	-	expression tag
Ala 84	-	expression tag
Ser 85	-	expression tag
Gly 267	-	expression tag
Ser 268	-	expression tag
His 269	-	expression tag
His 270	-	expression tag
His 271	-	expression tag
His 272	-	expression tag
His 273	-	expression tag
His 274	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	242707.2
Branched	Number of molecules	4
	Total formula weight	2282.2
Non-Polymers*	Number of molecules	18
	Total formula weight	2945.6
All*	Total formula weight	247935.0

*Water molecules are not included.